Oxidized LDL and LOX-1 in Experimental Sepsis
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منابع مشابه
Oxidized LDL and LOX-1 in Experimental Sepsis
Oxidized low-density lipoproteins (oxLDL) and the lectin-like oxLDL receptor-1 (LOX-1) are upregulated in inflammation. Because of the importance of inflammation and capillary leakage in the impairment of the microcirculation, which in turn contributes to the development of sepsis and multiorgan failure, the role of oxidized LDL and LOX-1 as players of intestinal inflammation is of great intere...
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Endothelial dysfunction and oxLDL are believed to be early and critical events in atherogenesis. 6-Shogaol is the major bioactive compound present in Zingiber officinale and possesses the anti-atherosclerotic effect. However, the mechanisms remain poorly understood. The goal of this study was to investigate the effects of 6-shogaol on oxLDL-induced Human umbilical vein endothelial cells (HUVECs...
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Oxidized low density lipoprotein (ox-LDL) and its scavenger receptor LOX-1 expression in osteoarthritis Aspasia Tsezou1,2,3, Theodora Simopoulou1, Lazaros Poultsides4, Sokratis Varitimidis4, Konstantinos N. Malizos3,4 1Department of Cytogenetics and Molecular Genetics, University of Thessalia, Larissa, Greece; 2Department of Biology, University of Thessalia, Larissa, Greece; 3Institute for Biom...
متن کاملThe hydrophobic tunnel present in LOX-1 is essential for oxidized LDL recognition and binding.
Lectin-like oxidized LDL (ox-LDL) receptor-1 (LOX-1) is a type-II transmembrane protein that belongs to the C-type lectin family of molecules. LOX-1 acts as a cell surface endocytosis receptor and mediates the recognition and internalization of ox-LDL by vascular endothelial cells. Internalization of ox-LDL by LOX-1 results in a number of pro-atherogenic cellular responses implicated in the dev...
متن کاملOxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects.
BACKGROUND C-reactive protein (CRP) exerts biological activity on vascular endothelial cells. This activity may promote atherothrombosis, but the effects of this activity are still controversial. Lectin-like oxidized LDL receptor-1 (LOX-1), the oxidized LDL receptor on endothelial cells, is involved in endothelial dysfunction induced by oxidized LDL. METHODS We used laser confocal microscopy ...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 2013
ISSN: 0962-9351,1466-1861
DOI: 10.1155/2013/761789